Curated List of Scientific Papers and Other Resources

AUGUST 18, 2021

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Bailey J. et al. Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings. Altern Lab Anim., 2021.

Bailey, J. Biomedical Research Must Change — But a Shift Toward Human-specific Research Methods Is Only Part of What Is Needed. Alternatives to Laboratory Animals., 2021.


Gupta R. et al. Comparing in vitro human liver models to in vivo human liver using RNA-Seq. Arch Toxicol, 2021, 95, 573–589. 


Qu Y et al. Inotropic assessment in engineered 3D cardiac tissues using human induced pluripotent stem cell-derived cardiomyocytes in the BiowireTM II platform. J Pharmacol Toxicol Methods. 2020 Sep;105:106886.


Lohasz C et al. Predicting Metabolism‐Related Drug–Drug Interactions Using a Microphysiological Multitissue System. Advanced Biosystems, 2020, 4(11).


Guo X et al. A Human‐Based Functional NMJ System for Personalized ALS Modeling and Drug Testing. Advanced Therapeutics, 2020, 3(11).


Donald E. Ingber. Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies? Advanced Science, 2020, 7(22).


Sasserath T et al. Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip. Advanced Science, 2020, 7(13).


Caneus J et al. A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ42 and tau‐induced pathophysiological effects on long‐term potentiation. Alzheimers Dement (N Y), 2020, 6(1).


Lin N et al. Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents. Sci Rep, 2020, 10, 8879.


Baert Y et al. A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model, Human Reproduction, 2020, 35(5), 1029–1044.


Schimek K. et al. Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies. Sci Rep, 2020, 10, 7865. 


Fonseca AC et al. Emulating Human Tissues and Organs: A Bioprinting Perspective Toward Personalized Medicine. Chem Rev, 2020, 120(19):11128-11174.


Marx U et al. Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. ALTEX, 2020, 37(3), 365-394.


Feric NT et al. Engineered Cardiac Tissues Generated in the Biowire II: A Platform for Human-Based Drug Discovery. Toxicological Sciences, 2019, 1–9.


Boos JA et al. Microfluidic Multitissue Platform for Advanced Embryotoxicity Testing In Vitro. Advanced Science, 2019, 6(13).


Materne EM et al. The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture. J Vis Exp, 2015 (98).


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Advancing new alternative methodologies at FDA. FDA, 2021.


Multi-Organ Microphysiological Systems are Poised for Expansive Integration. TissUse, 2020.


The evolution of strategies to minimise the risk of human DILI in drug discovery and development. Cyprotex, 2020.


Guides to ADME and Mechanisms of Drug-Induced Toxicity. Cyprotex, 2020.


Accelerating the Growth of Human-Relevant Sciences in the UK. The Alliance for Human-Relevant Science, 2020.


2019 State of the Discovery Nation Report, Medicines Discovery Catapult and the Bioindustry Association. New report unveils a thriving service and supply sector for UK medicines discovery | Medicines Discovery Catapult


2018 State of the Discovery Nation Report, Medicines Discovery Catapult and the Bioindustry Association. 


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Improving precision medicine with human tissue testing and genomics. Reprocell/Fios Genomics, 2021.


How Pharma is Using Human Tissues to Better Predict Drug Behaviour. Reprocell/Biopta, 2021.


Understanding the different approaches to 3D cell culture. Reprocell, 2021.


Human Tissue in Drug Discovery Scientific, Technical & Regulatory Perspective. Reprocell/Biopta, 2021.


Human biology: an exploration of organs-on-chips. Webinar, sponsored by Emulate and Genetic Engineering & Biotechnology News. 2021.


Terasaki Institute for Biomedical Innovation – Fireside Chat: “Minimizing Animal Models.” 2020.


Creating Scientific Marvels that are Works of Art – TED talk by Don Ingber, Director of the Wyss Institute.


This is your brain on chips. Wyss Institute.


How Translational Research is Key to Achieving Biomedical Impact. Maurizio Vecchione, for the Terasaki Institute. 2020.


Teach me in 10 – organs-on-a-chip. Ali Khademhosseini, Terasaki Institute, 2020.


Development of a novel dynamic blood brain barrier model using Kirkstall Quasi-Vivo system for studying brain diseases and cytotoxicity testing. Dr. Sikha Saha, University of Leeds, UK. For Kirkstall Ltd., UK.


Kidney, liver, and gut-on-a-chip model systems in toxicity testing; and brain- and placenta-on-a-chip. Webinar, Dr. Kristin Bircsak, MIMETAS, USA.


Human-on-a-chip. Hesperos Inc. USA. Florida Simulation Summit, 2020.


TissUse - HUMIMIC Chip2. 2018.


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Advances in In Vitro Models of Neurodegenerative Diseases. Emulate, 2021. 


Can Biosimulation Provide the Key to Unlocking the Neurodegenerative Disease Development Challenge? Van der Graaf P & Geerts H. 2021. AAPS Magazine.


How we established an in vitro Parkinson’s Disease model. Zara Puckrin, 2021. Reprocell, USA.


Advances in In Vitro Brain Modeling for Neuroinflammatory Disease Research. Emulate, 2020.


Reviving cells after a heart attack. Wyss Institute, 2020.


4 Examples of human models of respiratory diseases. Frederique Tholozan, 2020. Reprocell, USA.


4 reasons human tissues should be used to predict drug bioavailability. Zara Puckrin, 2020. Reprocell, USA.

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